Trifluoroacetic acid → 2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine trifluoroacetate

HRID 459446노트

반응식

HRID 459446 반응식
[Br:1][C:2]1[S:3][C:4]2[CH2:5][N:6](C(OC(C)(C)C)=O)[CH2:7][CH2:8][C:9]=2[N:10]=1.[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21]>ClCCl>[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21].[Br:1][C:2]1[S:3][C:4]2[CH2:5][NH:6][CH2:7][CH2:8][C:9]=2[N:10]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 111629512-Bromo-4,5,6,7-tetrahydro(1,3)thiazolo(5,4-c)pyridine, N-BOC protected

생성물 1

HCID 178425732-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Bromo-5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (890 mg) was dissolved in dichloromethane (2 ml), and to the solution trifluoroacetic acid (15 ml) was added, and the mixture was stirred at room temperature for 1 minute. The reaction mixture was concentrated under reduced pressure, and diethyl ether was added to the residue. Precipitated solid materials were collected by filtration to obtain the title compound (867 mg) as a colorless solid.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure, and diethyl ether
  2. additionwas added to the residue
  3. customPrecipitated solid materials
  4. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-cb50b3854890420c943ca5a025fb50d4
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192968B2

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