Potassium Carbonate → HCID 178419393, 화합물
반응식
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[Br:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Br)=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+]>>[Br:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][N:10]([CH2:16][C:15]2[CH:18]=[CH:19][C:12]([Br:11])=[CH:13][CH:14]=2)[C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)=[CH:14][CH:13]=1참가 물질
4
실험 절차
The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 4-bromobenzylbromide (550 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.153 g (32.5%); MS m/z: 472.3 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 4.63 (s, 4H); 6.66-6.67 (m, 1H); 6.71 (dd, 1H, 4J=2.4 Hz, 3J=8.9 Hz); 7.22-7.24 (m, 4H); 7.34 (d, 1H, 3J=8.9 Hz); 7.48-7.50 (m, 4H); 7.93 (s, 1H); 11.99 (br s, 1H; HPLC (METHOD [A]): rt 18.49 min (98.4%)
후처리
- customThe compound was synthesized
- custom