Potassium Carbonate → HCID 178419391, 화합물

HRID 45946

반응식

HRID 45946 반응식
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[Br:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15]Br.C([O-])([O-])=O.[K+].[K+]>>[Br:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15][N:10]([CH2:15][C:14]1[CH:17]=[CH:18][CH:19]=[C:12]([Br:11])[CH:13]=1)[C:8]1[CH:7]=[CH:6][C:5]2[NH:1][CH:2]=[N:3][C:4]=2[CH:9]=1

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 136235-AminobenzimidazoleHCID 699793-Bromobenzyl bromide

생성물 1

HCID 178419391HCID 178419391, 화합물

실험 절차

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 3-bromobenzylbromide (550 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.227 g (48.2%); MS m/z: 470.1/472.2/474.1 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 4.70 (s, 4H); 6.68-6.70 (m, 2H); 7.26-7.27 (m, 4H); 7.34 (d, 1H, 3J=8.6 Hz); 7.39-7.41 (m, 2H); 7.43 (s, 2H); 7.91 (s, 1H); 11.93 (br s, 1H); HPLC (METHOD [A]): rt 17.81 min (98.3%)

후처리

  1. customThe compound was synthesized
  2. customrt 17.81 min (98.3%)

출처 및 근거

ORD 기록
ord-f2abd80a766b4d87b5d44e1d7a8fe9e4
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541596B2

연결된 노트

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