Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrazinamide → Isoniazid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrazinamide | HCID 1046 | — |
| 반응물 | (+)-Lactose | HCID 440995 | — |
| 반응물 | (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;hydrochloride | HCID 16051971 | — |
| 반응물 | Rifampicin | HCID 135398735 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Isoniazid | HCID 3767 | — |
반응 단계
Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07195769B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-5e15d77afc0e48bba66338ba929a252c |
| 출처 메모 | uspto-grants-2007_03 |