Pyrazinamide → Isoniazid

HRID 459739

반응식

HRID 459739 반응식
N1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7](N)=O.CC[C@H](NCCN[C@H]([CH2:22][OH:23])CC)CO.Cl.CC1C2O[C@]3(C)OC=C[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)C=CC=C(C)C(NC4C(/C=[N:61]/[N:62]5CCN(C)CC5)=C(O)C(C=2C3=O)=C(C=4O)C=1O)=O.OC1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O>O>[CH:6]1[C:7]([C:22]([NH:61][NH2:62])=[O:23])=[CH:2][CH:3]=[N:4][CH:5]=1

참가 물질

6

반응물 4

HCID 1046PyrazinamideHCID 440995(+)-LactoseHCID 16051971(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;hydrochlorideHCID 135398735Rifampicin

생성물 1

HCID 3767Isoniazid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.

후처리

  1. customPass the wet mass through multimill and dry the granules at 50–60° C
  2. customPass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60
  3. additionmix with dried granules and isoniazid delayed release powder

출처 및 근거

ORD 기록
ord-5e15d77afc0e48bba66338ba929a252c
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07195769B2

연결된 노트

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