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Diethyl Ether → 1-Benzyl-6-fluoro-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one

HRID 459805
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HRID 459805 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]([F:24])=[CH:22][CH:21]=[C:20]3[C:15]=2[CH2:16][NH:17][C:18](=[O:32])[N:19]3[CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(OCC)C>Cl.C(O)C>[CH2:25]([N:19]1[C:20]2[C:15](=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[C:23]([F:24])=[CH:22][CH:21]=2)[CH2:16][NH:17][C:18]1=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 3283Diethyl EtherHCID 588241354-(1-Benzyl-6-fluoro-2-oxo-1,2,3,4-tetrahydro-quinazolin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 111636061-Benzyl-6-fluoro-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one

시약·촉매·용매 1

HCID 21887872Ethanol hydrochloride용매

반응 조건

온도
80 °C

실험 절차

4-(1-Benzyl-6-fluoro-2-oxo-1,2,3,4-tetrahydro-quinazolin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester (141 mg) was dissolved in 4 mL 2 N HCl/ethanol and heated to 80° C. for 20 minutes, then cooled to room temperature. Diethyl ether was added, precipitating 115 mg of 1-benzyl-6-fluoro-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one hydrochloride. MP: 285.6–290.0° C. MS: 341 (M+H)+.

후처리

  1. temperaturecooled to room temperature
  2. customprecipitating 115 mg of 1-benzyl-6-fluoro-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one hydrochloride

출처 및 근거

ORD 기록
ord-690cc064a04144e3885498f13a136abb
출처 데이터셋
uspto-grants-2007_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07196087B2

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