Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Carbonyldiimidazole → 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | N-Benzylaminodiacetic acid | HCID 77606 | — |
| 반응물 | 5-Aminoindole | HCID 78867 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione | HCID 22931025 | — |
반응 단계
N-Benzyliminodiacetic acid was reacted with CDI and 5-aminoindole in THF to obtain 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione, which was then reacted with lithium aluminum hydride in THF. Conc. hydrochloric acid and palladium hydroxide were added to an ethanol solution of thus obtained compound and the whole was reacted under a hydrogen atmosphere of 3 atm for 65 hours to obtain an objective compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196080B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-b6dd4d4e1f0746f5a86b715e167a3784 |
| 출처 메모 | uspto-grants-2007_03 |