1,1'-Carbonyldiimidazole → 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione

HRID 459849

반응식

HRID 459849 반응식
[CH2:1]([N:8]([CH2:13][C:14]([OH:16])=O)[CH2:9][C:10]([OH:12])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][CH:34]=[CH:33]2>C1COCC1>[CH2:1]([N:8]1[CH2:9][C:10](=[O:12])[N:29]([C:30]2[CH:31]=[C:32]3[C:36](=[CH:37][CH:38]=2)[NH:35][CH:34]=[CH:33]3)[C:14](=[O:16])[CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 77606N-Benzylaminodiacetic acidHCID 788675-Aminoindole

생성물 1

HCID 229310254-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-Benzyliminodiacetic acid was reacted with CDI and 5-aminoindole in THF to obtain 4-benzyl-1-(1H-indol-5-yl)piperazine-2,6-dione, which was then reacted with lithium aluminum hydride in THF. Conc. hydrochloric acid and palladium hydroxide were added to an ethanol solution of thus obtained compound and the whole was reacted under a hydrogen atmosphere of 3 atm for 65 hours to obtain an objective compound.

출처 및 근거

ORD 기록
ord-b6dd4d4e1f0746f5a86b715e167a3784
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196080B2

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