Benzyl Bromide → 3-(Benzyloxy)-2-bromo-6-iodopyridine

HRID 459851

반응식

[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([I:9])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([O:8][C:7]1[C:2]([Br:1])=[N:3][C:4]([I:9])=[CH:5][CH:6]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

반응물 3

HCID 7498Benzyl Bromide

HCID 11430Potassium Carbonate

HCID 109794792-Bromo-6-iodopyridin-3-ol

생성물 1

HCID 110255633-(Benzyloxy)-2-bromo-6-iodopyridine

실험 절차

2-Bromo-6-iodopyridin-3-ol was reacted with potassium carbonate and benzyl bromide to obtain 3-(benzyloxy)-2-bromo-6-iodopyridine, which was then reacted in a similar manner to Reference Example 11, Example 22 and Example 4, successively. Further, the resulting product was subjected to catalytic reduction using palladium/carbon to obtain an objective compound.

출처 및 근거

ORD 기록: ord-16b798cbc5e24f36bb7af0c1f45380de
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07196080B2

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