p-Fluoronitrobenzene → rel-(2R,5S)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

HRID 459853

반응식

HRID 459853 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][C@H:12]1[CH2:17][NH:16][C@H:15]([CH3:18])[CH2:14][NH:13]1>CN1C(=O)CCC1>[CH3:11][C@H:12]1[CH2:17][NH:16][C@H:15]([CH3:18])[CH2:14][N:13]1[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 9590p-FluoronitrobenzeneHCID 2206722,5-Dimethylpiperazine, trans-

생성물 1

HCID 57664370rel-(2R,5S)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

An NMP solution of fluoro-4-nitrobenzene and (±)-trans-2,5-dimethylpiperazine was stirred at an oil bath temperature of 120° C. for 3 hours to obtain (±)-trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine, which was further treated in a similar manner to Example 4 to obtain an objective compound.

출처 및 근거

ORD 기록
ord-eefa40e2896a40478a7d6d15383254f5
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196080B2

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