Borohydride → 3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-ol

HRID 459912

반응식

HRID 459912 반응식
[CH3:1][C:2]1([CH3:14])[CH2:7][O:6][C:5]2([CH2:12][CH2:11][C:10](=[O:13])[CH2:9][CH2:8]2)[O:4][CH2:3]1.[BH4-]>CO>[CH3:1][C:2]1([CH3:14])[CH2:3][O:4][C:5]2([CH2:8][CH2:9][CH:10]([OH:13])[CH2:11][CH2:12]2)[O:6][CH2:7]1

참가 물질

4

반응물 2

HCID 28123BorohydrideHCID 5879683,3-Dimethyl-1,5-dioxaspiro(5.5)undecan-9-one

생성물 1

HCID 124700963,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Combine 3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-one (Aldrich, 750 mg, 3.78 mmol) with polymer-supported borohydride (Aldrich, 3026 mg, 7.56 mmol) in methanol (30 mL). Shake by rotation the resulting mixture overnight. Filter the reaction mixture and concentrate the filtrate. Wash the residue with hydrochloric acid 0.1M and extract with EtOAc. Dry the organic layer over sodium sulfate, filter and concentrate.

후처리

  1. customthe resulting mixture overnight
  2. filtrationFilter the reaction mixture
  3. concentrationconcentrate the filtrate
  4. washWash the residue with hydrochloric acid 0.1M
  5. extractionextract with EtOAc
  6. dry with materialDry the organic layer over sodium sulfate
  7. filtrationfilter
  8. concentrationconcentrate

출처 및 근거

ORD 기록
ord-bfbde5ec2c73434e868e22d83e2af1ee
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196100B2

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