Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → 4-(1-Benzyl-piperidin-4-yloxy)-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 4-(Piperidin-4-yloxy)benzonitrile hydrochloride | HCID 17832273 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(1-Benzyl-piperidin-4-yloxy)-benzonitrile | HCID 11266328 | 95% |
반응 단계
Combine 4-(piperidin-4-yloxy)-benzonitrile hydrochloride (64 mg, 0.268 mmol), benzaldehyde (55 μL, 0.536 mmol) and sodium triacetoxy borohydride (85 mg, 0.402 mmol) in CH2Cl2 (3 mL). Stir at room temperature overnight. Dilute the reaction mixture with CH2Cl2 (3 mL) and wash with NaOH (1M aq. 5 mL). Separate the organic layer and place it in an SCX column, eluting with ammonia (2.0M in methanol) to provide the title compound (74 mg, 95%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196100B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-3a0e7436286b4c1089f4e4737f0fef18 |
| 출처 메모 | uspto-grants-2007_03 |