Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N-Diethyl-1,4-butanediamine → 1-Cyclopropyl-7-(4-diethylamino-butylamino)-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N-Diethyl-1,4-butanediamine | HCID 117976 | — |
| 반응물 | 1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one | HCID 18444694 | — |
| 반응물 | EtOH ethyl acetate triethylamine | HCID 22328969 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-Cyclopropyl-7-(4-diethylamino-butylamino)-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one | HCID 10323850 | 83% |
반응 단계
Using Procedure K, 0.63 g (1.48 mmol) of 1-cyclopropyl-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one and 4-(diethylamino)butylamine in 20 mL of dioxane were reacted. Chromatography with 9:1:0.5 ethyl acetate/ethanol/triethylamine gave 0.62 g (83%) of the title compound as a solid: mp 139° C.–141° C. MS (APCI) (m+1)/z 505.2. Analysis calculated for C25H34N6F2O3: C, 59.51; H, 6.79; N, 16.66. Found: C, 59.56; H, 6.77; N, 16.49.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196090B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-ad02a537a6d64c6a8d1abf44a0cc9f76 |
| 출처 메모 | uspto-grants-2007_03 |