Toluene → 1H-Indole-2,4-dicarboxylic acid 4-methyl ester

HRID 460007노트

반응식

HRID 460007 반응식
[CH3:1][O:2][C:3]([C:5]1[C:6]2[CH:7]=[C:8]([C:14]([O:16]C(C)(C)C)=[O:15])[NH:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)=[O:4].C1(C)C=CC=CC=1>C(O)(C(F)(F)F)=O>[CH3:1][O:2][C:3]([C:5]1[C:6]2[CH:7]=[C:8]([C:14]([OH:16])=[O:15])[NH:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)=[O:4]

참가 물질

4

반응물 2

HCID 1140TolueneHCID 688587391H-Indole-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester

생성물 1

HCID 695071401H-Indole-2,4-dicarboxylic acid 4-methyl ester

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

To a solution of 3.8 g 1H-Indole-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester were dissolved in 100 ml TFA. After 1 h at RT 150 ml toluene were added and the solvents were removed under reduced pressure. The residue was lyophilised after addition of water and acetonitrile. Yield: 2 g.

후처리

  1. customthe solvents were removed under reduced pressure
  2. additionafter addition of water and acetonitrile

출처 및 근거

ORD 기록
ord-a25b45ed7b9145c498fd80725359f84a
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196103B2

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