Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 460016생성일: 2026년 10월 25일
Triethyl phosphite → Diethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methylphosphonate
https://huagongshe.com/reaction/460016
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethyl phosphite | HCID 31215 | — |
| 반응물 | 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole | HCID 2794629 | — |
| 생성물 | Diethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methylphosphonate | HCID 86592483 | — |
반응 단계
A mixture of 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (intermediate 3, 1.48 g) and triethylphosphite (1.5 ml) was heated under nitrogen at 150° C. for 1 hour. The mixture was allowed to cool and excess triethylphosphite was removed under reduced pressure. This gave the title compound as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07196107B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_03 |
|---|
| ORD ID | ord-2bba9d4b39564aca80ec509faa4d516e |
|---|
| 출처 메모 | uspto-grants-2007_03 |
|---|
