Acetic Acid → 1-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidine-4-carbonitrile

HRID 46002

반응식

HRID 46002 반응식
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH2:13]([N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C:21]1=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C-:27]#[N:28].[K+].CC(O)=O>CO.O>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]([N:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)([C:27]#[N:28])[CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 9032Potassium CyanideHCID 705171-(4-Pyridyl)piperazineHCID 51700761-Benzyl-2-piperidone

생성물 1

HCID 686295031-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidine-4-carbonitrile수율 47%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution containing 1-(pyridin-4-yl)piperazine (58.34 mmol, 1 equiv.), N-benzyl-piperidinone (1 equiv.), KCN (1.1 equiv.), AcOH (3.3 ml) and water (1.3 ml) in methanol was stirred at room temperature for 16 h. The reaction mixture was quenched with NH4OH solution (400 ml) and filtered. The solid precipitate was thoroughly washed with water, dried under vacuum and taken through to the next reaction without further purification. Yield: 47%.

후처리

  1. customThe reaction mixture was quenched with NH4OH solution (400 ml)
  2. filtrationfiltered
  3. washThe solid precipitate was thoroughly washed with water
  4. customdried under vacuum
  5. customtaken through to the next reaction without further purification

출처 및 근거

ORD 기록
ord-4fa8de6172fc453393300fd777b7a17a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541573B2

연결된 노트

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