Ethanol → Ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate

HRID 460025

반응식

HRID 460025 반응식
C([C:3](Br)([CH2:9][CH3:10])[C:4](=O)[C:5]([O-:7])=[O:6])C.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[S:19])=[CH:16][CH:15]=1.[CH2:25](O)[CH3:26]>>[CH3:10][C:9]1[N:20]=[C:18]([C:17]2[CH:21]=[CH:22][C:14]([C:13]([F:12])([F:23])[F:24])=[CH:15][CH:16]=2)[S:19][C:3]=1[CH2:4][C:5]([O:7][CH2:25][CH3:26])=[O:6]

참가 물질

4

반응물 3

HCID 702EthanolHCID 27348234-(Trifluoromethyl)thiobenzamideHCID 86592485Ethyl-3-bromooxopentanoate

생성물 1

HCID 17972170Ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate

실험 절차

To a solution of ethyl-3-bromooxopentanoate (O. G. Kulinkovich e.t al., Synthesis, 1986, 378–379) (1.26 g) in absolute ethanol (6 ml) was added 4-(trifluoromethyl)thiobenzamide (1.24 g). The reaction was heated to reflux and stirred at this temperature for 18 hours under nitrogen. The mixture was then allowed to cool to room temperature, prior to cooling in ice. This resulted in crystallization of the product which was filtered and washed with ice cold ethanol to afford the title compound as beige crystals.

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux
  3. temperatureto cooling in ice
  4. customThis resulted in crystallization of the product which
  5. filtrationwas filtered
  6. washwashed with ice cold ethanol

출처 및 근거

ORD 기록
ord-e23ffdeada3e44a3a7648acd82a300a3
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196107B2

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