Ammonia → 3-(Morpholin-4-yl)propane-1-sulfonamide
반응식
[NH3:1].C(=O)=O.CC(C)=O.[N:9]1([CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>ClCCl>[N:9]1([CH2:15][CH2:16][CH2:17][S:18]([NH2:1])(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1참가 물질
5
실험 절차
Dichloromethane (40 ml) was saturated with ammonia gas with cooling (dry ice/acetone), and then 3-morpholin-4-yl-propane-1-sulphonyl chloride (279 mg, 1.23 mmoles) was added. The mixture was stirred at room temperature for 24 hours. The mixture was filtered, the filtrate evaporated and the residue was dried at 40° C. in vacuo to afford compound 58 (210 mg) as a gum. LC/MS System A; Rt=0.28 mins, m/z (ES+)=209 (M+H for C7H16N2O3S).
후처리
- filtrationThe mixture was filtered
- customthe filtrate evaporated
- customthe residue was dried at 40° C. in vacuo
출처 및 근거
- ORD 기록
- ord-08aaa0c8020a4cac883a5ab88ae23f8f
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07196089B2
반응 노트
불러오는 중…