1-(Quinolin-4-yl)ethanol → 1-(Quinolin-4-yl)ethan-1-one

HRID 460143노트

반응식

HRID 460143 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:13])[CH3:12])=[CH:3][CH:2]=1>ClCCl.[O-2].[Mn+2]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=[O:13])[CH3:12])=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 53147551-(Quinolin-4-yl)ethanol

생성물 1

HCID 123401901-(Quinolin-4-yl)ethan-1-one수율 100%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

To the mixture of manganese oxide (8.69 g, 100 mmol, Aldrich) in dichloromethane (80 mL) was added 1-quinolin-4-yl-ethanol (1.73 g, 10 mmol). The reaction mixture was refluxed for overnight and then cooled to room temperature. The solid was filtered out through Celite pad. The organic solution dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 100% yield (1.71 g, 10.0 mmol).

후처리

  1. temperatureThe reaction mixture was refluxed for overnight
  2. filtrationThe solid was filtered out through Celite pad
  3. dry with materialThe organic solution dried over anhydrous magnesium sulfate
  4. concentrationconcentrated via vacuo

출처 및 근거

ORD 기록
ord-7cac8f31b4584785b737b061818ea1a0
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196102B2

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