5-Methoxyindan-1-one → 2-(6-methoxy-1H-inden-3-yl)propanoic Acid

반응식

[O:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=O)[CH2:7][CH2:6]2)[CH3:2].Br[CH:14]([CH3:19])[C:15]([O:17]C)=[O:16]>>[CH3:2][O:1][C:3]1[CH:4]=[C:5]2[C:9]([C:8]([CH:14]([CH3:19])[C:15]([OH:17])=[O:16])=[CH:7][CH2:6]2)=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 787875-Methoxyindan-1-one

HCID 95576Methyl 2-bromopropionate

생성물 1

HCID 219427692-(6-methoxy-1H-inden-3-yl)propanoic Acid수율 68%

실험 절차

This substrate was prepared using the same procedures as described for Examples 1 and 2a, starting with 5-methoxyl-1-indanone and methyl 2-bromopropionate. Yield: 68%. 1H NMR (CD2Cl2) δ 7.34 (d, J=9, 1H), 7.07 (d, J=2, 1H), 6.85 (dd, J=9, J=2, 1H), 6.32 (m, 1H), 3.82 (m, 4H), 3.36 (m, 2H), 1.56 (d, J=7, 3H).

후처리

customThis substrate was prepared

출처 및 근거

ORD 기록: ord-798cad91915e4029b13d37a40ba46f77
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08541618B2

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