Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 1-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 7-Bromo-1,3-dioxaindane-5-carbaldehyde | HCID 2320243 | — |
| 반응물 | HCID 178418918 | HCID 178418918 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol | HCID 18445394 | 96.4% |
반응 단계
To a solution of 7-bromo-benzo[1,3]dioxole-5-carbaldehyde (437 mg, 1.91 mmol) in dry ether (6 mL) was added slowly under argon at −30° C. isopropylmagnesium chloride (1.15 mL, 2.0 M in ether, 2.29 mmol) and the solution stirred for 30 minute. A solution of aqueous ammonium chloride was added and the layers separated. The aqueous layer was extrated with ethyl acetate and the organic combined and washed with water, brine, dried (MgSO4), filtered and evaporated to give 503 mg of 1-(7-bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196108B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-2cb68651744b4569b1e4bc0ac9ee3e60 |
| 출처 메모 | uspto-grants-2007_03 |