Ammonium Chloride → 1-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol

HRID 460309

반응식

HRID 460309 반응식
[Br:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]=[O:12])[CH:3]=1.[CH:13]([Mg]Cl)([CH3:15])[CH3:14].[Cl-].[NH4+]>CCOCC>[Br:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]([OH:12])[CH:13]([CH3:15])[CH3:14])[CH:3]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 23202437-Bromo-1,3-dioxaindane-5-carbaldehydeHCID 178418918HCID 178418918, 화합물

생성물 1

HCID 184453941-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol수율 96.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 7-bromo-benzo[1,3]dioxole-5-carbaldehyde (437 mg, 1.91 mmol) in dry ether (6 mL) was added slowly under argon at −30° C. isopropylmagnesium chloride (1.15 mL, 2.0 M in ether, 2.29 mmol) and the solution stirred for 30 minute. A solution of aqueous ammonium chloride was added and the layers separated. The aqueous layer was extrated with ethyl acetate and the organic combined and washed with water, brine, dried (MgSO4), filtered and evaporated to give 503 mg of 1-(7-bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol.

후처리

  1. customthe layers separated
  2. washwashed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-2cb68651744b4569b1e4bc0ac9ee3e60
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196108B2

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