참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dibromomethane | HCID 3024 | — |
| 반응물 | 5-Bromo-3,4-dihydroxybenzaldehyde | HCID 85405 | — |
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-Bromo-1,3-dioxaindane-5-carbaldehyde | HCID 2320243 | 60.5% |
반응 단계
To a solution of 3-bromo-4,5-dihydroxy-benzaldehyde (1.52 g, 7.02 mmol) in DMF (20 mL), were added KF (4.077 g, 70.18 mmol) followed by dibromomethane (1 mL, 14.04 mmol) and the mixture heated at 140° C. for 4 hours. The solution was cooled to room temperature, water was added and the mixture extracted with ether. The organic layer was further washed with saturated aqueous NaHCO3, dried (MgSO4), filtered and evaporated to give 973 mg of 7-bromo-benzo[1,3]dioxole-5-carbaldehyde. 1H NMR (300 MHz; CDCl3): δ 6.16 (s, 2H), 7.26 (s, 1H), 7.54 (s, 1H), 9.76
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07196108B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_03 |
|---|
| ORD ID | ord-0d38999cde49444faa0534a1045bfd1b |
|---|
| 출처 메모 | uspto-grants-2007_03 |
|---|
