Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Methyl 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylate | HCID 619692 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylic Acid | HCID 10752341 | — |
반응 단계
The mixture consisting of 500 mg of methyl 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylate, 160 mg of lithium hydroxide, 2 ml of water, 2 ml of THF and 2 ml of methanol is stirred at RT for 3 days. After dilution with 15 ml of water, unhydrolyzed ester is removed by extraction with ethyl acetate. The aqueous phase is adjusted to pH 5 using hydrochloric acid and stirred, and the precipitated solid is filtered off with suction and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196114B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-2c96ff4f637f4338b0e2cb3a6cd9e194 |
| 출처 메모 | uspto-grants-2007_03 |