Toluene → Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

HRID 460427

반응식

HRID 460427 반응식
[F:1][C:2]([F:21])([F:20])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8].S(Cl)(Cl)=O.[C:26]1(C)C=CC=CC=1>CO>[F:1][C:2]([F:20])([F:21])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:6]=1[C:7]([O:9][CH3:26])=[O:8]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 27360782,5-bis(2,2,2-trifluoroethoxy)benzoic Acid

생성물 1

HCID 2727094Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid (20 g) and thionyl chloride (15.0 g) in methanol (100 ml) was stirred at 80° C. for 2 hours. The solvents were evaporated under vacuum to give an oil residue. Toluene (100 ml) was added to the residue and the solution was washed with saturated NaHCO3 (30 ml) solution followed by water (3×30 ml). The organic layer was concentrated under reduced pressure to give the product as a white solid (20.5 g, yield 98.0%).

후처리

  1. customThe solvents were evaporated under vacuum
  2. customto give an oil residue
  3. washthe solution was washed with saturated NaHCO3 (30 ml) solution
  4. concentrationThe organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8a2a5e9993e74072941f4e4b4d260e81
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196197B2

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