Acetonitrile → 1-Benzylpyrrolidine-3-carbonitrile

HRID 460437

반응식

HRID 460437 반응식
CS(O[CH:6]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7]1)(=O)=O.C(=O)(O)[O-].[Na+].[C:23](#[N:25])C>[C-]#N.C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:11]([N:8]1[CH2:9][CH2:10][CH:6]([C:23]#[N:25])[CH2:7]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 516892Sodium BicarbonateHCID 98998111-Benzylpyrrolidin-3-yl methanesulfonate

생성물 1

HCID 46745791-Benzylpyrrolidine-3-carbonitrile

시약·촉매·용매 1

HCID 165872Tetrabutylammonium Cyanide촉매

실험 절차

A mixture of EXAMPLE 1G (1.5 g) and tetrabutlyammonium cyanide (3.15 gm) in acetonitrile (25 mL) was heated at 65° C. for 24 hours, poured into saturated aqueous sodium bicarbonate, and extracted with toluene. The extract was washed with distilled water, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, CDCl3) δ 7.33 (s, 5H), 3.42 (m, 2H), 2.89 (m, 1H), 2.72 (m, 1H), 1.68 (b, 3H), 1.45 (m, 2H).

후처리

  1. extractionextracted with toluene
  2. washThe extract was washed with distilled water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ee0fd30836f540f28cd0f0bb79e4b6c3
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196200B2

연결된 노트

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