Ammonia → 2-(Methylthio)pyrimidin-4-amine

HRID 460440

반응식

HRID 460440 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[NH3:10]>CO>[CH3:9][S:8][C:4]1[N:3]=[C:2]([NH2:10])[CH:7]=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 971134-Chloro-2-methylthiopyrimidine

생성물 1

HCID 2592252-(Methylthio)pyrimidin-4-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

후처리

  1. temperaturecooled
  2. concentrationconcentrated
  3. additiontreated with water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated
  8. customThe concentrate was triturated with ethyl ether
  9. filtrationfiltered

출처 및 근거

ORD 기록
ord-d0f51b1d18cf40e7b1cd4b0b3fd62358
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196200B2

연결된 노트

불러오는 중…