Benzenepropanoic acid → 3-(4-Iodophenyl)propanoic acid

HRID 460493

반응식

HRID 460493 반응식
[C:1]([OH:11])(=[O:10])[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[I:12](O)(=O)(=O)=O.S(=O)(=O)(O)O.II>O.C(O)(=O)C>[I:12][C:7]1[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][C:1]([OH:11])=[O:10])=[CH:9][CH:8]=1

참가 물질

7

반응물 4

HCID 107Benzenepropanoic acidHCID 807IodineHCID 1118Sulfuric AcidHCID 65185Metaperiodic acid

생성물 1

HCID 2332383-(4-Iodophenyl)propanoic acid수율 460.8%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매2회

반응 조건

온도
105 °C

실험 절차

Hydrocinnamic acid is iodinated to form 4-iodohydrocinnamic acid. The process is performed by mixing 201.2 g hydrocinnamic acid, 1 L acetic acid, 152 mL water, 52.8 g periodic acid, 76 mL sulfuric acid, and 144 g iodine. The mixture is heated at 105° C. for 6.5 hours. Next, 200 mL water is added, and the mixture is cooled to room temperature overnight. The solid product in the resultant mixture is filtered and washed with water, yielding 350 g unpurified 4-iodohydrocinnamic acid. Further purification is not necessary and is not conducted, and the product is used as is in the second step.

후처리

  1. temperaturethe mixture is cooled to room temperature overnight
  2. filtrationThe solid product in the resultant mixture is filtered
  3. washwashed with water

출처 및 근거

ORD 기록
ord-c4543b6f2743498eaf89c9a303be194c
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196214B2

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