Water → 4-(8-hydroxy-2H-chromen-3-ylcarbonyl)morpholine

HRID 460548노트

반응식

HRID 460548 반응식
C[O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][C:9]([C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14])=[CH:8]2.B(Br)(Br)Br.O>C(Cl)Cl>[OH:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][C:9]([C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14])=[CH:8]2

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 107548644-(8-methoxy-2H-chromen-3-ylcarbonyl)morpholine

생성물 1

HCID 105633504-(8-hydroxy-2H-chromen-3-ylcarbonyl)morpholine수율 99.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution (70 ml) of 4-(8-methoxy-2H-chromen-3-ylcarbonyl)morpholine (3.5 g) in methylene chloride was added dropwise boron tribromide (9.5 g) at −78° C. The reaction temperature was set to room temperature and the mixture was stirred for 2 hr. The reaction mixture was poured into water and stirred for 1 hr. The organic layer was separated and washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (3.3 g) as brown crystals.

후처리

  1. customwas set to room temperature
  2. stirringstirred for 1 hr
  3. customThe organic layer was separated
  4. washwashed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-59d077f9f5c044e7af2e0266a3a9785e
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196199B2

반응 노트

불러오는 중…