Methanol → HCID 22762275, 화합물

HRID 460737노트

반응식

HRID 460737 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([NH:16][C:17]2[CH:22]=[C:21]([NH:23][C:24](=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:20]=[CH:19][C:18]=2[Cl:39])=[N:11]1.[CH3:40][OH:41].[OH2:42]>C(#N)C>[Cl:9][C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]=[C:12]([NH:16][C:17]2[CH:22]=[C:21]([NH:23][C:24](=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:20]=[CH:19][C:18]=2[Cl:39])[N:11]1[C:40]([O:42][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:41]

참가 물질

5

반응물 3

HCID 887MethanolHCID 962Water2회HCID 178443172N-[4-chloro-3-[[5-oxo-1-(2,4,6-trichlorophenyl)-4H-pyrazol-3-yl]amino]phenyl]tetradecanamide

생성물 1

HCID 22762275HCID 22762275, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 30.7 g (0.05 mole) of 1-(2,4,6-trichlorophenyl)-3-(2-chloro-5-myristoylamino-anilino)-2-pyrazolin-5-one and 15.6 g (0.1 mole) of phenyl chloroformiate in 100 ml of acetonitrile are refluxed for 4 h. The solution is poured out in water and the separated oil is stirred first with water and next with methanol. The precipitate is recrystallized from ethanol.

후처리

  1. customThe precipitate is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-be249b6a1114491a91def0ad79430d48
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061498

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