N,N'-Dimethylthiourea → 4-(3,4-Dimethyl-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide

HRID 460828노트

반응식

HRID 460828 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([CH3:15])=[C:7]([CH3:16])[CH:6]=1)=[O:4].[CH3:17][NH:18][C:19]([NH:21][CH3:22])=[S:20]>>[BrH:1].[CH3:16][C:7]1[CH:6]=[C:5]([C:3]2([OH:4])[CH2:2][S:20][C:19](=[N:18][CH3:17])[N:21]2[CH3:22])[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]=1[CH3:15]

참가 물질

3

반응물 2

HCID 2723631N,N'-DimethylthioureaHCID 213947832-Bromo-3',4'-dimethyl-5'-sulfamoylacetophenone

생성물 1

HCID 213947544-(3,4-Dimethyl-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide

실험 절차

3.1 g of 2-bromo-3',4'-dimethyl-5'-sulfamoyl-acetophenon were reacted according to the method described in Example 6 with 1.1 g of 1,3-dimethyl-thiourea and the 4-(3,4-dimethyl-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide was filtered off. M.p. 252°-255° C (decomposition).

후처리

  1. filtrationthe 4-(3,4-dimethyl-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide was filtered off

출처 및 근거

ORD 기록
ord-e299688c5f68483b9780bbb34e181b73
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061647

반응 노트

불러오는 중…