p-Toluenesulfonic acid → HCID 20367252, 화합물

HRID 460916노트

반응식

HRID 460916 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][NH:6][NH2:7].C([O:16][C:17](=O)[CH:18]=[C:19]([NH2:23])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[NH2:23][C:19]1[NH:7][N:6]([CH2:5][C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[C:2]([F:12])([F:13])[F:1])[C:17](=[O:16])[CH:18]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl esterHCID 20367279{[2-(Trifluoromethyl)phenyl]methyl}hydrazine

생성물 1

HCID 20367252HCID 20367252, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

46 g of 2-trifluoromethylbenzylhydrazine were added dropwise, under nitrogen, to a solution of 38.2 g of β-amino-β-ethoxyacrylic acid ethyl ester and 2 g of p-toluenesulphonic acid in 250 ml of ethanol. After stirring overnight, the solvent was distilled off in vacuo and the residue was recrystallized from ethanol. The product was the compound identified above. Melting point: 184°, 22 g (34%).

후처리

  1. distillationthe solvent was distilled off in vacuo
  2. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-cb261811cccd43a5bcb681a1d4b56aa2
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061653

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