p-Toluenesulfonic acid → HCID 20367243, 화합물

HRID 460923노트

반응식

HRID 460923 반응식
C([O:3][C:4](=O)[CH:5]=[C:6]([NH2:10])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1.[Cl:23][C:24]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:25]=1[CH2:26][NH:27][NH2:28]>C(O)C>[NH2:10][C:6]1[NH:28][N:27]([CH2:26][C:25]2[CH:29]=[C:30]([Cl:33])[CH:31]=[CH:32][C:24]=2[Cl:23])[C:4](=[O:3])[CH:5]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl esterHCID 20367285[(2,5-Dichlorophenyl)methyl]hydrazine

생성물 1

HCID 20367243HCID 20367243, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

32.8 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1 g of p-toluenesulphonic acid were dissolved in 120 ml of ethanol and 39 g of 2,5-dichlorobenzylhydrazine were added under nitrogen. After stirring for 2 hours the mixture was left to stand overnight and the compound identified above, which precipitated, was filtered off and recrystallised from ethanol. Melting point: 195°-196° C; Yield: 23 g (43%).

후처리

  1. waitwas left
  2. waitto stand overnight
  3. customprecipitated
  4. filtrationwas filtered off
  5. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-c52d449a6c2949bc9c75c073081c5c4f
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061653

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