rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride → cis-2-Cyclohexylcyclopentylamine hydrochloride

HRID 461036

반응식

HRID 461036 반응식
[ClH:1].[C:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>O>[ClH:1].[CH:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

참가 물질

4

반응물 2

HCID 70051154rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochlorideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 70050481cis-2-Cyclohexylcyclopentylamine hydrochloride수율 33.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Using rhodium-on-charcoal catalyst in a Paar shaker, 12.6 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 204°-206° C in 100 ml of water is hydrogenated. In 20 hours when the theoretical amount of hydrogen has been taken up the catalyst is removed by filtration, the filtrate made basic with sodium hydroxide solution, and the resulting precipitate is extracted into ether. After evaporation of the ether the residue is distilled, M.P. 100°-102° C (6.0 mm). The hydrochloride salt is prepared and recrystallized from isopropanol-ether to give 4.4 g of cis-2-(cyclohexyl)cyclopentylamine hydrochloride, M.P 174°-176° C.

후처리

  1. customthe catalyst is removed by filtration
  2. extractionthe resulting precipitate is extracted into ether
  3. customAfter evaporation of the ether the residue
  4. distillationis distilled
  5. customrecrystallized from isopropanol-ether

출처 및 근거

ORD 기록
ord-b1ccc48a7cd842fdbd02fff0a3afa683
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061746

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