HCID 11160380, 화합물 → 6-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

HRID 461097노트

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HRID 461097 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([CH3:16])[C:11]([O:13]CC)=O)=[CH:5][CH:4]=1>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:6]([CH2:9][CH:10]([CH3:16])[C:11]2=[O:13])=[CH:7][CH:8]=1

참가 물질

3

반응물 1

HCID 11160380HCID 11160380, 화합물

생성물 1

HCID 2311786-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

시약·촉매·용매 1

HCID 962Water용매

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온도
50 °C

실험 절차

Ethyl β-(p-methoxyphenyl)-α-methylpropionate is added to 56 g of polyphosphoric acid with stirring at 50° C. The mixture is then heated to 83°-90° C for two hours. The cooled reaction mixture is poured slowly into a mixture of water and crushed ice with stirring and extracted with 3 × 300 ml of ether. The etheral solution is washed with 10% sodium bicarbonate solution followed by cold water to neutral, then with saturated sodium chloride solution and dried over magnesium sulfate for 1.5 hours and filtered. The solvent is removed on an evaporator and the residue distilled to obtain 6-methoxy-2-methylindanone.

후처리

  1. temperatureThe mixture is then heated to 83°-90° C for two hours
  2. customThe cooled reaction mixture
  3. customcrushed ice
  4. stirringwith stirring
  5. extractionextracted with 3 × 300 ml of ether
  6. washThe etheral solution is washed with 10% sodium bicarbonate solution
  7. dry with materialdried over magnesium sulfate for 1.5 hours
  8. filtrationfiltered
  9. customThe solvent is removed on an evaporator
  10. distillationthe residue distilled

출처 및 근거

ORD 기록
ord-4dfc247c4f014ead8560c679c455836a
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061771

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