Sodium Bicarbonate → 4-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol

HRID 461115

반응식

HRID 461115 반응식
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:19])[CH2:13][S:12][C:11](=[N:14][CH:15]([CH3:17])[CH3:16])[N:10]2[CH3:18])=[CH:5][C:4]=1[S:20](=[O:23])(=[O:22])[NH2:21].C(=O)(O)[O-].[Na+]>O>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:19])[CH2:13][S:12][C:11](=[N:14][CH:15]([CH3:17])[CH3:16])[N:10]2[CH3:18])=[CH:5][C:4]=1[S:20](=[O:22])(=[O:23])[NH2:21]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 227604664-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

생성물 1

HCID 227604674-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
40 °C

실험 절차

7 g of ground 4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide were dissolved in 80 ml of 40° C hot water and stirred for 30 minutes at 40° C after adding it to a mixture of 60 ml of saturated sodium bicarbonate solution and 100 ml of water. After cooling to room temperature, the mixture was extracted with 200 ml of diethyl ether, the organic phase was dried over sodium sulfate and the solvent was distilled off under reduced pressure. The residue was dissolved in 40 ml of diisopropyl ether and the end product was precipitated by pouring it into 200 ml of stirred petroluem ether.

후처리

  1. additionafter adding it
  2. temperatureAfter cooling to room temperature
  3. extractionthe mixture was extracted with 200 ml of diethyl ether
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. distillationthe solvent was distilled off under reduced pressure
  6. dissolutionThe residue was dissolved in 40 ml of diisopropyl ether
  7. customthe end product was precipitated
  8. additionby pouring it into 200 ml of stirred petroluem ether

출처 및 근거

ORD 기록
ord-715146bac3044d5ab2f3833a6eb7a0b8
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061761

연결된 노트

불러오는 중…