Dicyclohexylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 461134

반응식

HRID 461134 반응식
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:22][C:23]([NH:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:24][C:23](=[N:22][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[N:25]2[CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

참가 물질

3

반응물 2

HCID 727200DicyclohexylthioureaHCID 21316749HCID 21316749, 화합물

생성물 1

HCID 227605234-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

실험 절차

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 4.8 g of 1,3-dicyclohexylthiourea were reacted according to the prescription made in Example 12, the end product was precipitated with 200 ml of diethyl ether and the oil was crystallized after decanting the solvent with diethyl ether. Colorless, crystalline solid body: melting point: 177° C (from acrylonitrile).

후처리

  1. customthe end product was precipitated with 200 ml of diethyl ether
  2. customthe oil was crystallized
  3. customafter decanting the solvent with diethyl ether

출처 및 근거

ORD 기록
ord-0cba33b3992a44f6a9575dbd8486e604
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061761

연결된 노트

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