4-(2-(4-Methyl-3-nitrophenoxy)ethyl)morpholine → 2-Methyl-5-[2-(morpholin-4-yl)ethoxy]aniline

HRID 46114노트

반응식

HRID 46114 반응식
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:4][C:3]=1[N+:17]([O-])=O>CO.[Pd]>[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:4][C:3]=1[NH2:17]

참가 물질

4

반응물 1

HCID 589298674-(2-(4-Methyl-3-nitrophenoxy)ethyl)morpholine

생성물 1

HCID 393350392-Methyl-5-[2-(morpholin-4-yl)ethoxy]aniline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To the mixture of 4-(2-(4-methyl-3-nitrophenoxy)ethyl)morpholine (532 mg, 2 mmol) in MeOH (50 mL) was added 10% Pd/C (250 mg). The mixture was stirred under an atmosphere of H2 (balloon) overnight. The contents of the reaction mixture were then filtered and concentrated in vacuo to give the title product, which was used without further purification.

후처리

  1. filtrationThe contents of the reaction mixture were then filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b92268b26e0144e1b41cb66cb5379de2
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541592B2

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