Thionyl Chloride → 4-Isopropyl-3-sulfamoylbenzoylchloride

반응식

[CH:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](O)=[O:9])=[CH:6][C:5]=1[S:13](=[O:16])(=[O:15])[NH2:14])([CH3:3])[CH3:2].S(Cl)([Cl:19])=O>>[CH:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([Cl:19])=[O:9])=[CH:6][C:5]=1[S:13](=[O:16])(=[O:15])[NH2:14])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 167729934-(Propan-2-yl)-3-sulfamoylbenzoic acid

생성물 1

HCID 227605054-Isopropyl-3-sulfamoylbenzoylchloride

실험 절차

5 g of 4-isopropyl-3-sulfamoylbenzoic acid were boiled under reflux in 50 ml of thionylchloride until completely dissolved and the reaction mixture was then concentrated to 25 ml under reduced pressure. After allowing to dwell over night at 0° C, the crystals were filtered off over a sinter glass frit and washed with petroleum ether. Colorless body, melting point: 177° C.

후처리

dissolutionuntil completely dissolved
concentrationthe reaction mixture was then concentrated to 25 ml under reduced pressure
waitto dwell over night at 0° C
filtrationthe crystals were filtered off over a sinter glass frit
washwashed with petroleum ether

출처 및 근거

ORD 기록: ord-214e4131f8ad4597b2e7c479c445e79f
출처 데이터셋: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04061761

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