Triethylamine → 4-(4-Chloro-3-cyclopropylsulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

HRID 461177노트

반응식

HRID 461177 반응식
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[CH2:13][S:12][C:11](=[N:14][CH3:15])[N:10]2[CH3:16])=[CH:5][C:4]=1[S:18](Cl)(=[O:20])=[O:19].[CH:22]1([NH2:25])[CH2:24][CH2:23]1.C(N(CC)CC)C>C(O)C>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[CH2:13][S:12][C:11](=[N:14][CH3:15])[N:10]2[CH3:16])=[CH:5][C:4]=1[S:18](=[O:20])(=[O:19])[NH:25][CH:22]1[CH2:24][CH2:23]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 69828CyclopropylamineHCID 227604894-Chloro-3-chlorosulfonylphenyl-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide

생성물 1

HCID 227604484-(4-Chloro-3-cyclopropylsulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6.6 g of 4-(4-chloro-3-chlorosulfonylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide were reacted as prescribed in Example 76 with 1.5 g of cyclopropyl amine and 4 g of triethyl amine in 50 ml of ethanol and worked up. Fair yellow crystals, melting point: 180° C (decomposition).

출처 및 근거

ORD 기록
ord-55156e1694c34522a2798eed7fc11fe2
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061761

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