Methanol → 4-(4-n-Hexylpyrimid-2-yl)benzoic acid amide

HRID 461310노트

반응식

HRID 461310 반응식
Cl.[C:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].[CH2:14]([C:20](=[CH:23]OCC)C=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[CH3:27][O-].[Na+].CO>CCOCC>[CH2:15]([C:14]1[CH:20]=[CH:23][N:3]=[C:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][CH:6]=2)[N:4]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH3:27]

참가 물질

6

반응물 4

HCID 887MethanolHCID 27242934-Amidinobenzamide HydrochlorideHCID 10942334Sodium MethoxideHCID 542364922-n-Hexyl-3-ethoxy-acrolein

생성물 1

HCID 541836714-(4-n-Hexylpyrimid-2-yl)benzoic acid amide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

0.082 mol of 4-amidino-benzoic acid amide hydrochloride, suspended in a solution of 0.082 mol of 2-n-hexyl-3-ethoxy-acrolein and 0.14 mol of sodium methylate in 150 ml. of methanol, are stirred overnight at room temperature under an atmosphere of nitrogen. The precipitate obtained by diluting the reaction mixture with 3.1 of ether is removed by filtration, washed with water until neutral and dried at 40° in a vacuum drying cabinet, whereby 17.9 g. of 4-(4-n-hexylpyrimid-2-yl)benzoic acid amide are obtained, m.p. 231.6° - 233.0°.

후처리

  1. customThe precipitate obtained
  2. customis removed by filtration
  3. washwashed with water until neutral and
  4. customdried at 40° in a vacuum
  5. customdrying cabinet, whereby 17.9 g

출처 및 근거

ORD 기록
ord-2384ed2869fd4d3cb928e419bf92b052
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062798

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