HCID 178422083, 화합물 → HCID 178422098, 화합물
반응식
C12CC(CC1)C[C@@H]2NC1SC(C)(CC2CCNCC2)C(=O)N=1.[CH:23]12[CH2:29][CH:26]([CH2:27][CH2:28]1)[CH2:25][C@@H:24]2[NH:30][C:31]1[S:32][C:33]([CH2:38][CH:39]2[CH2:44][CH2:43][N:42]([C:45]([C:47]3[CH:48]=[C:49]([CH:61]=[CH:62][CH:63]=3)[O:50][CH2:51][CH2:52][NH:53]C(=O)OC(C)(C)C)=[O:46])[CH2:41][CH2:40]2)([CH3:37])[C:34](=[O:36])[N:35]=1>>[NH2:53][CH2:52][CH2:51][O:50][C:49]1[CH:48]=[C:47]([CH:63]=[CH:62][CH:61]=1)[C:45]([N:42]1[CH2:43][CH2:44][CH:39]([CH2:38][C:33]2([CH3:37])[S:32][C:31]([NH:30][C@H:24]3[CH2:25][CH:26]4[CH2:29][CH:23]3[CH2:28][CH2:27]4)=[N:35][C:34]2=[O:36])[CH2:40][CH2:41]1)=[O:46]참가 물질
3
실험 절차
The title compound was prepared according to the procedure described in the preparation of 2-((2S)-bicyclo[2.2.1]heptan-2-ylamino)-5-methyl-5-(piperidin-4-ylmethyl)thiazol-4(5H)-one by using tert-butyl 2-(3-(4-((2-((2S)-bicyclo[2.2.1]heptan-2-ylamino)-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl)methyl)piperidine-1-carbonyl)phenoxy)ethylcarbamate (689 mg, 1.18 mmol) as the starting material. The title compound was obtained as an off-white solid (531 mg). MS (ESI, pos. ion) m/z: 485 (M+H)
후처리
- customThe title compound was prepared
출처 및 근거
- ORD 기록
- ord-afdc2e93269742faae0d9d2acafb0ea0