Morpholine → 2-Diethylaminomethyl-3-morpholinomethylnaphthalene

HRID 461451노트

반응식

HRID 461451 반응식
[Br-].[CH2:2]([N+:4]1([CH2:17][CH3:18])[CH2:12][C:11]2[CH:10]=[C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]3=[CH:7][C:6]=2[CH2:5]1)[CH3:3].[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH2:2]([N:4]([CH2:5][C:6]1[C:11]([CH2:12][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:10][C:9]2[C:8](=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=1)[CH2:17][CH3:18])[CH3:3]

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 44658157HCID 44658157, 화합물

생성물 1

HCID 213937262-Diethylaminomethyl-3-morpholinomethylnaphthalene

실험 절차

2,2-Diethylbenz[f]isoindolinium bromide (13 g) was refluxed with morpholine (150 ml) for 30 hr. Morpholine was evaporated and the residue was partitioned between sodium hydroxide solution and ether; the ether layer was evaporated to dryness and the residue purified by chromatography [eluent, diethylamine:cyclohexane = 1:4, silica (250 g)] and distillation to give 2-diethylaminomethyl-3-morpholinomethylnaphthalene, b.p. 160°/0.015 mm.

후처리

  1. customMorpholine was evaporated
  2. customthe residue was partitioned between sodium hydroxide solution and ether
  3. customthe ether layer was evaporated to dryness
  4. distillationthe residue purified by chromatography [eluent, diethylamine:cyclohexane = 1:4, silica (250 g)] and distillation

출처 및 근거

ORD 기록
ord-f9b5fa629ce3460b9a2170bba00c5af6
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062955

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