Potassium Carbonate → 4-(m-Benzoylphenyl)-2-butanone

HRID 461520

반응식

HRID 461520 반응식
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7].[C:17]([CH2:20]C(=O)C)(=[O:19])[CH3:18].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[C:6]([C:5]1[CH:4]=[C:3]([CH2:2][CH2:18][C:17](=[O:19])[CH3:20])[CH:16]=[CH:15][CH:14]=1)(=[O:7])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 895863-(Bromomethyl)benzophenone

생성물 1

HCID 204960404-(m-Benzoylphenyl)-2-butanone수율 39.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3-bromomethylbenzophenone (2.75 g.), acetylacetone (1 g.), potassium carbonate (1.4 g.) and ethanol (50 ml) was refluxed for 2 hours. The solvent was then evaporated and the residue extracted with ether. Distillation of the concentrated extracts gave 4-(m-benzoylphenyl)-2-butanone (1 g.), b.p. 220° C (4 mm). [An alternative preparation of this compound appears in German Offenlegungsschrift No. 2,243,444].

후처리

  1. temperaturewas refluxed for 2 hours
  2. customThe solvent was then evaporated
  3. extractionthe residue extracted with ether
  4. distillationDistillation of the concentrated extracts

출처 및 근거

ORD 기록
ord-f75ab447997a45649acb9e00944ff338
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062978

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