Methyl isothiocyanate → Metiamide

HRID 461528노트

반응식

HRID 461528 반응식
C(=O)([O-])[O-].[K+].[K+].Cl.Cl.[CH3:9][C:10]1[N:11]=[CH:12][NH:13][C:14]=1[CH2:15][S:16][CH2:17][CH2:18][NH2:19].[CH3:20][N:21]=[C:22]=[S:23]>O>[CH3:20][NH:21][C:22]([NH:19][CH2:18][CH2:17][S:16][CH2:15][C:14]1[N:13]=[CH:12][NH:11][C:10]=1[CH3:9])=[S:23]

참가 물질

5

반응물 3

HCID 11167Methyl isothiocyanateHCID 11430Potassium CarbonateHCID 30159992-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride

생성물 1

HCID 1548992Metiamide

시약·촉매·용매 1

HCID 962Water용매

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온도
5 °C

실험 절차

Potassium carbonate (7.75 g.) was added to a solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (14.6 g.) in water (120 ml.). The solution was stored at room temperature for 15 minutes and methyl isothiocyanate (5.15 g.) was added. After heating under reflux for 30 minutes, the solution was slowly cooled to 5° C. The product was collected and recrystallized from water to give N-methyl-N'-[2-((5-methyl-4-imidazolyl)-methylthio)ethyl]thiourea, m.p. 150°-152° C.

후처리

  1. temperatureAfter heating
  2. temperatureunder reflux for 30 minutes
  3. customThe product was collected
  4. customrecrystallized from water

출처 및 근거

ORD 기록
ord-91b438b35fe445da9a4cf430fa471cbd
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04063023

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