Methylamine → HCID 178484998, 화합물

HRID 461530노트

반응식

HRID 461530 반응식
[CH3:1][NH2:2].[C:3]([NH:5][C:6](=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])SC)#[N:4]>C(O)C>[C:3]([NH:5][C:6]([NH:2][CH3:1])=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])#[N:4]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 1036301-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea

생성물 1

HCID 178484998HCID 178484998, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of methylamine in ethanol (33%, 75 ml.) was added to a solution of N-cyano-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-S-methylisothiourea (10.1 g.) in ethanol (30 ml). The reaction mixture was set aside at room temperature for 2.5 hours. Following concentration under reduced pressure, the residue was recrystallized twice from isopropyl alcohol/petroleum ether, affording N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)-ethyl]guanidine, m.p. 141°-143° C.

후처리

  1. concentrationconcentration under reduced pressure
  2. customthe residue was recrystallized twice from isopropyl alcohol/petroleum ether

출처 및 근거

ORD 기록
ord-5e70d313cbfe4f26b46e53cdadf4cbd3
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04063023

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