Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Furoic acid → HCID 178461996, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Furoic acid | HCID 10268 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | HCID 178461995 | HCID 178461995 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178461996 | HCID 178461996 | — |
반응 단계
The mixture of 5-(3-(cyclopropylamino)propyl)-5-methyl-2-((S)-1-(2-(trifluoromethyl)-phenyl)ethylamino)thiazol-4(5H)-one (0.106 g, 0.265 mmol), 3-furoic acid (0.0297 g, 0.265 mmol), TBTU (0.0895 g, 0.279 mmol), and N,N-diisopropylethylamine (0.0555 ml, 0.318 mmol) in DMF (3.0 mL) was stirred at ambient temp. overnight. The mixture was partitioned between EtOAc and Na2CO3 (aq), and the combined organic portions were washed with brine. The solvents were removed in vacuo, and the residue was purified by flash column chromatography (0 to 100% of EtOAc in hexanes) to give the title compound as a white solid. MS m/z: 494.1 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541592B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-3ffbf3b2e5b44cd2845d9281c95246be |
| 출처 메모 | uspto-grants-2013_09 |