4-Chloro-3-nitrobenzophenone → {4-[Methyl(octyl)amino]-3-nitrophenyl}(phenyl)methanone

HRID 461626

반응식

HRID 461626 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1Cl)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])([O-:3])=[O:2].[CH3:19][NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>C(O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[N:20]([CH3:19])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 417434-Chloro-3-nitrobenzophenoneHCID 75538Octylmethylamine

생성물 1

HCID 23342777{4-[Methyl(octyl)amino]-3-nitrophenyl}(phenyl)methanone

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 9.23 g. of 3-nitro-4-chloro-benzophenone, 10 ml. of ethanol and 10.3 g. of N-methyl-N-octylamine is stirred at 80° to 85° C for 30 minutes, and then the mixture is poured onto 100 ml. of ice water. The aqueous phase is extracted with 2x75 ml. of benzene. The benzene phases are combined, washed with distilled water with chloride-free, dried over anhydrous magnesium sulphate, filtered, and evaporated in vacuo. 11.57 g. of 3-nitro-4-(N-methyl-N-octylamino)-benzophenone are obtained in the form of an oily residue. On the basis of thin layer chromatographical examination, a pure, uniform product is obtained.

후처리

  1. additionA mixture of 9.23 g
  2. additionthe mixture is poured onto 100 ml
  3. extractionThe aqueous phase is extracted with 2x75 ml
  4. washwashed with distilled water with chloride-free
  5. dry with materialdried over anhydrous magnesium sulphate
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-5008c09bbebb4d06a7beba95648bd188
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064121

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