Phenethylamine → HCID 20394044, 화합물

HRID 461648노트

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HRID 461648 반응식
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=O.[CH2:16]([NH2:24])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C=CC=CC=1>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=[N:24][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 1001PhenethylamineHCID 29959682-[3-(Dimethylamino)propoxy]benzaldehyde

생성물 1

HCID 20394044HCID 20394044, 화합물수율 74.8%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
50 °C

실험 절차

A solution of 32.5 g of 2-(3-dimethylaminopropoxy)-benzaldehyde and 18.9 g of phenethylamine in 150 ml of toluene is heated at reflux for one hour. After 30 minutes, 1 mole equivalent of water is collected in a Dean-Stark trap. After cooling to approximately 50° C, the solvent is removed using a rotary evaporator and the oily residue is distilled to give 36.2 g of the title compound, boiling point 165°-167° C at 0.05 mm of Hg.

후처리

  1. temperatureat reflux for one hour
  2. custom1 mole equivalent of water is collected in a Dean-Stark trap
  3. customthe solvent is removed
  4. customa rotary evaporator
  5. distillationthe oily residue is distilled

출처 및 근거

ORD 기록
ord-9d694d1bfdb146d0baab31304d97bf45
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064125

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