Ammonia → 2,6-Dinitro-4-(trifluoromethyl)aniline

HRID 461666

반응식

HRID 461666 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([C:11]([F:14])([F:13])[F:12])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].[NH3:18].C(O)C>C(OCC)(=O)C>[NH2:18][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([C:11]([F:14])([F:13])[F:12])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 702EthanolHCID 98094-Chloro-3,5-dinitrobenzotrifluoride

생성물 1

HCID 99362,6-Dinitro-4-(trifluoromethyl)aniline

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Twenty six grams (0.096m) of crude 4-chloro-3,5-dinitrobenzotrifluoride, 150 ml. of liquid ammonia and 150 ml. of 2B ethanol were heated in a sealed autoclave at 100° C. for about 4 hours. After cooling and venting, the reaction mixture was taken up in ethyl acetate. The ethyl acetate phase was washed with water. The ethyl acetate solution was dried and evaporated in vacuo to yield crude 4-amino-3,5-dinitrobenzotrifluoride.

후처리

  1. temperatureAfter cooling
  2. washThe ethyl acetate phase was washed with water
  3. dry with materialThe ethyl acetate solution was dried
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6c74e5568ac744b987452968520ce2e3
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064127

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